Beyond Spike Proteins: Researchers Suggest New Design for Longer Lasting Covid Vaccines:
"With new COVID variants and subvariants evolving faster and faster, each chipping away at the effectiveness of the leading vaccines, the hunt is on for a new kind of vaccine," reports the Daily Beast, "one that works equally well on current and future forms of the novel coronavirus. "Now researchers at the National Institutes of Health in Maryland think they've found a new approach to vaccine design that could lead them to a long-lasting jab. As a bonus, it also might work on other coronaviruses, not just the SARS-CoV-2 virus that causes COVID-19." The NIH team reported its findings in a peer-reviewed study that appeared in the journal Cell Host & Microbe earlier this month. The key to the NIH's potential vaccine design is a part of the virus called the "spine helix." It's a coil-shaped structure inside the spike protein, the part of the virus that helps it grab onto and infect our cells. Lots of current vaccines target the spike protein. But none of them specifically target the spine helix. And yet, there are good reasons to focus on that part of the pathogen. Whereas many regions of the spike protein tend to change a lot as the virus mutates, the spine helix doesn't. That gives scientists "hope that an antibody targeting this region will be more durable and broadly effective," Joshua Tan, the lead scientist on the NIH team, told The Daily Beast.... A vaccine that binds the spine helix in SARS-CoV-2 should hold up for a long time. And it should also work on all the other coronaviruses that also include the spine helix — and there are dozens of them, including several such as SARS-CoV-1 and MERS that have already made the leap from animal populations and caused outbreaks in people.... Maybe a spine-helix jab is in our future. Or maybe not. Either way, it's encouraging that scientists are making incremental progress toward a more universal coronavirus vaccine. One that could work for many years on a wide array of related viruses.
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