Mouse Sperm Thrived Despite Six Years of Exposure To Space Radiation
In the longest biological experiment on the International Space Station yet, freeze-dried mouse sperm remained viable after nearly six years in space. Exposure to space radiation didn't seem to harm the sperm's DNA or the cells' ability to produce healthy "space pups," researchers report in Science Advances. Science News reports: That may be good news for future spacefarers. Scientists have worried that chronic exposure to space radiation might not only put astronauts at risk for cancer and other diseases, but also create mutations in their DNA that could be passed down to future generations. The new results hint that deep-space travelers could safely bear children. Studying how space radiation affects reproduction is tricky. Instruments on Earth can't perfectly mimic space radiation, and the ISS lacks freezers for long-term cell storage. So biologist Teruhiko Wakayama of the University of Yamanashi in Kofu, Japan and colleagues freeze-dried sperm, allowing it to be stored at room temperature. The team then sent sperm from 12 mice to the space station, while keeping other sperm from the same mice on the ground. After returning the sperm cells to Earth, rehydrating them and injecting them into fresh mouse eggs, the team transferred those embryos to female mice. About 240 healthy space pups were born from sperm kept on the ISS for nearly three years; about 170 others were born from sperm kept on the space station for nearly six years. Genetic analyses revealed no differences between these space pups and mice born from sperm stored on the ground. Space pups that mated as adults had healthy children and grandchildren.
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